Association of Severe Respiratory Syncytial Virus Bronchiolitis with Interleukin‐4 and Interleukin‐4 Receptor α Polymorphisms
نویسندگان
چکیده
منابع مشابه
Human Metapneumovirus in Severe Respiratory Syncytial Virus Bronchiolitis
Reverse transcription-polymerase chain reaction was used to detect segments of the M (matrix), N (nucleoprotein), and F (fusion) genes of human metapneumovirus in bronchoalveolar fluid from 30 infants with severe respiratory syncytial virus bronchiolitis. Seventy percent of them were coinfected with metapneumovirus. Such coinfection might be a factor influencing the severity of bronchiolitis.
متن کاملRespiratory Syncytial Virus Infection and Bronchiolitis
4. Learn the epidemiologic and experimental information suggesting the existence of a link between early-life infection with RSV and the subsequent development of recurrent wheezing and asthma in childhood and adolescence. AUTHORDISCLOSUREDr Perez has disclosed no financial relationships relevant to this article. Dr Piedimonte has disclosed he receives research grant NHLBI HL-061007 from the Na...
متن کاملImmunopathogenesis of respiratory syncytial virus bronchiolitis.
BACKGROUND The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis. METHODS Children <24 months old who presented to the emergency department with clinical symptoms of bronchiolitis were prospectively enrolled in the study....
متن کاملProduction of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis.
BACKGROUND Respiratory syncytial virus (RSV) bronchiolitis in infants is characterized by a massive neutrophilic infiltrate into the airways. Chemokines direct migration of leukocytes and contribute to the pathogenesis of RSV disease. However, little is known about pulmonary chemokine responses to RSV in humans. Our aim was to characterize the production of chemokines in the lungs of infants wi...
متن کاملHigh incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis.
BACKGROUND Respiratory syncytial virus (RSV) is the most common cause of viral lower respiratory tract infections (LRTI). Viral LRTI is a risk factor for bacterial superinfection, having an escalating incidence with increasing severity of respiratory illness. A study was undertaken to determine the incidence of pulmonary bacterial co-infection in infants and children with severe RSV bronchiolit...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2003
ISSN: 0022-1899,1537-6613
DOI: 10.1086/345859